Epigenetics of Trained Innate Immunity

The Scientist » News & Opinion » Daily News              Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages. By Ruth Williams | September 25, 2014   WIKIMEDIA, CHRISTOPH BOCK (MAX PLANCK INSTITUTE FOR INFORMATICS) Genome-wide epigenetic and transcription analyses of monocytes...

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Targeted Brain Cancer Vaccine

The Scientist » News & Opinion » Daily News             Mouse study demonstrates the ability of a cancer vaccine targeted against a specific oncogenic mutation to elicit a protective anti-tumor immune response. By Anna Azvolinsky | June 25, 2014   NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES A vaccine targeting a mutation found in a subset...

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Blood-based tests for colorectal cancer screening

Worldwide, screening has been shown to reduce mortality and incidence of colorectal cancer. Despite its documented success, people still fail to participate and screening rates remain low in most countries. Given that patient-reported barriers include resistance to recommended fecal-based methods or endoscopy, blood-based tests have the potential to increase participation in colorectal cancer screening programmes.by Dr Theo deVos   Different...

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The Scientist> The Nutshell> WHO: TB’s Toll Worse Than Thought

A new report from the World Health Organization finds that tuberculosis has infected hundreds of thousands more people around the world than was estimated a year ago. By Bob Grant | October 22, 2014   Mycobacterium tuberculosis, the bug that causes TB WIKIMEDIA, NIAID    Tuberculosis (TB) is causing more infections and deaths the world over than previous estimates indicated, according to a new survey released by...

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The Nutshell: Tumor Exosomes Make microRNAs

Tumor Exosomes Make microRNAs Cellular blebs shed by tumor cells can process short stretches of RNA that go on to induce tumor formation in neighboring cells. By Kerry Grens | October 27, 2014   WIKIMEDIA, NATIONAL CANCER INSTITUTE Cells give off little membrane-bound bubbles called exosomes, which are known to contain microRNAs (miRNAs)—short stretches of RNA that can interfere with protein production. Exosomes have also been...

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Immune cells in experimental acute kidney injury

Nature Reviews Nephrology:   The immune system has a vital role in the renal response to acute kidney injury (AKI). In this Review, Hye Ryoun Jang and Hamid Rabb describe current understanding of the function of the innate and adaptive immune systems in the early and late injury phases of ischaemic and nephrotoxic AKI, and describe the influence of immune cells on recovery and long-term outcome following AKI.    Abstract:   Acute...

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Male infertility: a public health issue caused by sexually transmitted pathogens

Nature Reviews Urology:   Sexually transmitted diseases caused by bacteria, viruses and protozoa can affect the male genital tract. Gimenes and colleagues discuss the evidence for effects of sexually transmitted pathogens on semen, sperm and male infertility.   Fabrícia Gimenes,1, Raquel P. Souza,1, Jaqueline C. Bento,3, Jorge J. V. Teixeira,2, Silvya S. Maria-Engler,4, Marcelo G. Bonini5, & Marcia E. L. Consolaro1,   Published...

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