A Long Line of LINEs
Different mechanisms repress mobile DNA elements in human embryonic stem cells depending on the elements’ evolutionary ages.
By Kate Yandell | September 1, 2014
ROUTES
TO REPRESSION: The oldest LINE-1 transposons in the human genome are no
longer transcribed due to the accumulation of mutations (1).
DNA-binding proteins called KRAB-ZFPs and their partner KAP1 repress
slightly younger LINE-1s, which originated...
